Eveningness chronotype and depressive affective temperament associated with higher high-sensitivity C-Reactive Protein in Unipolar and Bipolar Depression

Introduction Several studies investigated the role of inflammation in etiopathogenesis psychiatric disorders, by also evaluating how CRP may exert a pathoplastic and/or psychopatological mood disorders. Objectives The aim our cross-sectional study is high-sensitivity C-reactive-protein (hsCRP) levels cohort unipolar and bipolar depressive inpatients, relation with psychopathological, temperamental chronotype features. Methods Among 313 screened we recruited 133 moderate-to-severe patients who were assessed for hsCRP levels, Morningness-Eveningness Questionnaire (MEQ) affective temperament Temperament Evaluation Memphis, Pisa, Paris San Diego (TEMPS). Results significantly higher among those previous suicide attempt (p=0.05), death (p=0.018) self-harm/self-injury thoughts (p=0.011). In addition, hypertension (p=0.020) dyslipidemia (p=0.013). Moreover, positive correlation found between number illness years (p<0.001). Significant (p<0.001) cyclothymic temperaments, while negative correlations reported hypertimic irritable (p=0.029) temperaments. Eveningness chronotypes subject displayed compared to intermediate-type morningness-type Linear regression analyses, adjusted all covariates, demonstrated that scores at TEMPS-M depressive, lower hyperthymic temperaments [F=88.955, R 2 =0.710, p<0.001] MEQ [F=75.456, =0.405, statistically predicted hsCRP. Conclusions appeared be associated during depression. Further longitudinal larger should better characterise disorders investigating influence temperament. Disclosure Interest None Declared